Far, far improved debugger. The debugger dialog has gone (yay!), and lots of the "clunkyness" has been removed (now I will actually start using it more!). You can now set break-points when the debugger is not running, step into arbitary scripts, etc. The debugging experience is far closer to MSVC. A few notes on the new debugger are here.
Integration with IDLE extensions. Many of the new Pythonwin features below have come about simply by stealing code from IDLE :-).
Dockable interactive window and path browser. PathBrowser can now browse into the modules themselves (if you get the very latest pyclbr.py, it works even better!)
Fully customisable keyboard configuration and extensions. You can define your own keyboard bindings and also your own custom events!
Improved auto-indentation and tab usage, thanks to the Tab Wizard <wink> himself.
IDLE's "ExpandWord" extension used - excellent feature - start typing a variable name or any other word, hit Alt+/, and the word auto-completes.
Interactive Window has stolen IDLE's history capability, and now has full support for triple-quoted strings, "_", etc (this now uses the standard code.py module)
Integrated class browser with every editor window.
Support for simple toggling and definition of fixed and propertional fonts.
Small improvements to the grep facility.
Improved call tips and attribute expansion.
Key binding for toggling between the interactive window and the most recently used editor window.
Far improved find facility, including the ability to search across all open files.
Quite a few more little improvements. Already I don't know how I lived without some of these!

Here is the obligatory screen-shot!

If you are not already a registered user, then you will need to build Pythonwin from the sources (or even better, register and help support the life and development of these cool Python extensions!)

[Wed Jul 27 08:02:53 2005 GMT+10]